Glucagonlike peptide-1 receptor: an example of translational research in insulinomas: a review

Christ, Emanuel; Wild, Damian; Reubi, Jean-Claude (2010). Glucagonlike peptide-1 receptor: an example of translational research in insulinomas: a review. Endocrinology and metabolism clinics of North America, 39(4), pp. 791-800. Philadelphia, Pa.: Elsevier 10.1016/j.ecl.2010.09.003

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Glucagonlike peptide-1 receptors (GLP-1R) play an increasingly important role in endocrine gastrointestinal tumor management. In particular, virtually all benign insulinomas express GLP-1R in high density. Exendin-4 is a GLP-1 analog that has a longer half-life than GLP-1. Targeting GLP-1R by (111)In-DOTA-exendin-4 or (111)In-DPTA-exendin-4 offers a new approach that permits the successful localization of small benign insulinomas. It is likely that this new noninvasive technique has the potential to replace the invasive localization by selective arterial stimulation and venous sampling.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Endocrinology, Diabetology and Clinical Nutrition

UniBE Contributor:

Christ, Emanuel and Reubi-Kattenbusch, Jean-Claude

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0889-8529

Publisher:

Elsevier

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:09

Last Modified:

14 Oct 2019 16:59

Publisher DOI:

10.1016/j.ecl.2010.09.003

PubMed ID:

21095545

Web of Science ID:

000285850800009

URI:

https://boris.unibe.ch/id/eprint/791 (FactScience: 200863)

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