Gestation-specific reference intervals for comprehensive spot urinary steroid hormone metabolite analysis in normal singleton pregnancy and 6 weeks postpartum

Mistry, Hiten Dhirubhai; Eisele, Nicole; Escher, Geneviève; Dick, Bernhard; Surbek, Daniel; Delles, Christian; Currie, G; Schlembach, Dieter; Mohaupt, Markus; Gennari, Carine (2015). Gestation-specific reference intervals for comprehensive spot urinary steroid hormone metabolite analysis in normal singleton pregnancy and 6 weeks postpartum. Reproductive biology and endocrinology, 13(101), pp. 1-13. BioMed Central 10.1186/s12958-015-0100-6

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BACKGROUND: Normal pregnancy depends on pronounced adaptations in steroid hormone concentrations. Although in recent years, the understanding of these hormones in pregnancy has improved, the interpretation is hampered by insufficient reference values. Our aim was to establish gestation-specific reference intervals for spot urinary steroid hormone levels in normal singleton pregnancies and 6 weeks postpartum. METHODS: Cross-sectional multicentre observational study. Women recruited between 2008 and 2013 at 3 University Hospitals in Switzerland (Bern), Scotland (Glasgow) and Austria (Graz). Spot urine was collected from healthy women undergoing a normal pregnancy (age, 16-45 years; mean, 31 years) attending routine antenatal clinics at gestation weeks 11, 20, and 28 and approximately 6 weeks postpartum. Urine steroid hormone levels were analysed using gas-chromatography mass spectrometry. Creatinine was also measured by routine analysis and used for normalisation. RESULTS: From the results, a reference interval was calculated for each hormone metabolite at each trimester and 6 weeks postpartum. Changes in these concentrations between trimesters and postpartum were also observed for several steroid hormones and followed changes proposed for index steroid hormones. CONCLUSIONS: Normal gestation-specific reference values for spot urinary steroid hormones throughout pregnancy and early postpartum are now available to facilitate clinical management and research approaches to steroid hormone metabolism in pregnancy and the early postpartum period.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Mistry, Hiten Dhirubhai; Eisele, Nicole; Escher, Geneviève; Dick, Bernhard; Surbek, Daniel; Mohaupt, Markus and Gennari, Carine

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1477-7827

Publisher:

BioMed Central

Funders:

[4] Swiss National Science Foundation
[63] ERA-EDTA Fellowship
[64] NHS Greater Glasgow & Clyde Endowment Grant

Language:

English

Submitter:

Geneviève Escher

Date Deposited:

22 Mar 2016 11:21

Last Modified:

22 Mar 2016 11:21

Publisher DOI:

10.1186/s12958-015-0100-6

PubMed ID:

26337185

Uncontrolled Keywords:

Pregnancy reference values; Urine; Steroid metabolites

BORIS DOI:

10.7892/boris.79741

URI:

https://boris.unibe.ch/id/eprint/79741

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