Differential cell cycle and proliferation marker expression in ductal pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia (PanIN)

Karamitopoulou, Eva; Zlobec, Inti; Tornillo, Luigi; Carafa, Vincenza; Schaffner, Thomas; Brunner, Thomas; Borner, Markus; Diamantis, Ioannis; Zimmermann, Arthur; Terracciano, Luigi (2010). Differential cell cycle and proliferation marker expression in ductal pancreatic adenocarcinoma and pancreatic intraepithelial neoplasia (PanIN). Pathology, 42(3), pp. 229-34. London: Wolters Kluwer Lippincott Williams & Wilkins 10.3109/00313021003631379

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Pancreatic cancer is an aggressive tumour following a multistep progression model through precursors called pancreatic intraepithelial neoplasia (PanIN). Identification of reliable prognostic markers would help in improving survival. The aim of this study was to investigate the role as well as the prognostic significance of different cell cycle and proliferation markers, namely p21, p27, p53 and Ki-67, in pancreatic carcinogenesis.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology
04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Medical Oncology

UniBE Contributor:

Schaffner, Thomas; Brunner, Thomas; Borner, Markus and Zimmermann, Arthur

ISSN:

0031-3025

Publisher:

Wolters Kluwer Lippincott Williams & Wilkins

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:09

Last Modified:

04 May 2014 23:04

Publisher DOI:

10.3109/00313021003631379

PubMed ID:

20350215

Web of Science ID:

000276085300006

URI:

https://boris.unibe.ch/id/eprint/803 (FactScience: 200877)

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