A Specific Mapping Study Using Fluorescence Sentinel Lymph Node Detection in Patients with Intermediate- and High-risk Prostate Cancer Undergoing Extended Pelvic Lymph Node Dissection.

Nguyen, Daniel Truong Phat; Huber, Philipp Markus; Metzger, Tobias Alfred; Genitsch Gratwohl, Vera; Schudel, Hans; Thalmann, George (2016). A Specific Mapping Study Using Fluorescence Sentinel Lymph Node Detection in Patients with Intermediate- and High-risk Prostate Cancer Undergoing Extended Pelvic Lymph Node Dissection. European urology, 70(5), pp. 734-737. Elsevier 10.1016/j.eururo.2016.01.034

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Sentinel lymph node (SLN) detection techniques have the potential to change the standard of surgical care for patients with prostate cancer. We performed a lymphatic mapping study and determined the value of fluorescence SLN detection with indocyanine green (ICG) for the detection of lymph node metastases in intermediate- and high-risk patients undergoing radical prostatectomy and extended pelvic lymph node dissection. A total of 42 patients received systematic or specific ICG injections into the prostate base, the midportion, the apex, the left lobe, or the right lobe. We found (1) that external and internal iliac regions encompass the majority of SLNs, (2) that common iliac regions contain up to 22% of all SLNs, (3) that a prostatic lobe can drain into the contralateral group of pelvic lymph nodes, and (4) that the fossa of Marcille also receives significant drainage. Among the 12 patients who received systematic ICG injections, 5 (42%) had a total of 29 lymph node metastases. Of these, 16 nodes were ICG positive, yielding 55% sensitivity. The complex drainage pattern of the prostate and the low sensitivity of ICG for the detection of lymph node metastases reported in our study highlight the difficulties related to the implementation of SNL techniques in prostate cancer. PATIENT SUMMARY There is controversy about how extensive lymph node dissection (LND) should be during prostatectomy. We investigated the lymphatic drainage of the prostate and whether sentinel node fluorescence techniques would be useful to detect node metastases. We found that the drainage pattern is complex and that the sentinel node technique is not able to replace extended pelvic LND.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology
04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Nguyen, Daniel Truong Phat; Huber, Philipp Markus; Metzger, Tobias Alfred; Genitsch Gratwohl, Vera; Schudel, Hans and Thalmann, George

Subjects:

600 Technology > 610 Medicine & health
500 Science > 570 Life sciences; biology

ISSN:

0302-2838

Publisher:

Elsevier

Language:

English

Submitter:

Katharina Morgenegg

Date Deposited:

08 Jun 2016 09:18

Last Modified:

11 Sep 2017 08:47

Publisher DOI:

10.1016/j.eururo.2016.01.034

PubMed ID:

26856960

Uncontrolled Keywords:

Indocyanine green; Lymphadenectomy; Mapping; Prostate cancer; Sentinel lymph node

BORIS DOI:

10.7892/boris.80964

URI:

https://boris.unibe.ch/id/eprint/80964

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