Effects of Breastfeeding on Respiratory Symptoms in Infancy.

Gorlanova, Olga; Thalmann, Simone; Proietti, Elena; Stern, Georgette; Latzin, Philipp; Kühni, Claudia; Röösli, Martin; Frey, Urs (2016). Effects of Breastfeeding on Respiratory Symptoms in Infancy. Journal of pediatrics, 174, 111-117.e5. Elsevier 10.1016/j.jpeds.2016.03.041

	Text Gorlanova JPediatrics 2016.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (530kB)
Preview	Text Gorlanova JPediatrics 2016_postprint.pdf - Accepted Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (1MB) | Preview

OBJECTIVE

To assess the impact of potential risk factors on the development of respiratory symptoms and their specific modification by breastfeeding in infants in the first year of life.

STUDY DESIGN

We prospectively studied 436 healthy term infants from the Bern-Basel Infant Lung Development cohort. The breastfeeding status, and incidence and severity of respiratory symptoms (score) were assessed weekly by telephone interview during the first year of life. Risk factors (eg, pre- and postnatal smoking exposure, mode of delivery, gestational age, maternal atopy, and number of older siblings) were obtained using standardized questionnaires. Weekly measurements of particulate matter <10 μg were provided by local monitoring stations. The associations were investigated using generalized additive mixed model with quasi Poisson distribution.

RESULTS

Breastfeeding reduced the incidence and severity of the respiratory symptom score mainly in the first 27 weeks of life (risk ratio 0.70; 95% CI 0.55-0.88). We found a protective effect of breastfeeding in girls but not in boys. During the first 27 weeks of life, breastfeeding attenuated the effects of maternal smoking during pregnancy, gestational age, and cesarean delivery on respiratory symptoms. There was no evidence for an interaction between breastfeeding and maternal atopy, number of older siblings, child care attendance, or particulate matter <10 μg.

CONCLUSIONS

This study shows the risk-specific effect of breastfeeding on respiratory symptoms in early life using the comprehensive time-series approach.

Interest & Impact

Downloads

104 since deposited on 18 Apr 2016
11 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item