Effects of Breastfeeding on Respiratory Symptoms in Infancy.

Gorlanova, Olga; Thalmann, Simone; Proietti, Elena; Stern, Georgette; Latzin, Philipp; Kühni, Claudia; Röösli, Martin; Frey, Urs (2016). Effects of Breastfeeding on Respiratory Symptoms in Infancy. Journal of pediatrics, 174, 111-117.e5. Elsevier 10.1016/j.jpeds.2016.03.041

[img] Text
Gorlanova JPediatrics 2016.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (530kB) | Request a copy
Gorlanova JPediatrics 2016_postprint.pdf - Accepted Version
Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND).

Download (1MB) | Preview

OBJECTIVE To assess the impact of potential risk factors on the development of respiratory symptoms and their specific modification by breastfeeding in infants in the first year of life. STUDY DESIGN We prospectively studied 436 healthy term infants from the Bern-Basel Infant Lung Development cohort. The breastfeeding status, and incidence and severity of respiratory symptoms (score) were assessed weekly by telephone interview during the first year of life. Risk factors (eg, pre- and postnatal smoking exposure, mode of delivery, gestational age, maternal atopy, and number of older siblings) were obtained using standardized questionnaires. Weekly measurements of particulate matter <10 μg were provided by local monitoring stations. The associations were investigated using generalized additive mixed model with quasi Poisson distribution. RESULTS Breastfeeding reduced the incidence and severity of the respiratory symptom score mainly in the first 27 weeks of life (risk ratio 0.70; 95% CI 0.55-0.88). We found a protective effect of breastfeeding in girls but not in boys. During the first 27 weeks of life, breastfeeding attenuated the effects of maternal smoking during pregnancy, gestational age, and cesarean delivery on respiratory symptoms. There was no evidence for an interaction between breastfeeding and maternal atopy, number of older siblings, child care attendance, or particulate matter <10 μg. CONCLUSIONS This study shows the risk-specific effect of breastfeeding on respiratory symptoms in early life using the comprehensive time-series approach.

Item Type:

Journal Article (Original Article)


04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Paediatric Medicine
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM)

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Proietti, Elena; Stern Meggers, Georgette; Latzin, Philipp and Kühni, Claudia


600 Technology > 610 Medicine & health
300 Social sciences, sociology & anthropology > 360 Social problems & social services






[4] Swiss National Science Foundation




Beatrice Minder Wyssmann

Date Deposited:

18 Apr 2016 11:06

Last Modified:

23 Jan 2020 05:13

Publisher DOI:


PubMed ID:


Uncontrolled Keywords:

breastfeeding; infants interaction; longitudinal study; respiratory symptoms





Actions (login required)

Edit item Edit item
Provide Feedback