Gut Microbiota Orchestrates Energy Homeostasis during Cold.

Chevalier, Claire; Stojanović, Ozren; Colin, Didier J; Suarez-Zamorano, Nicolas; Tarallo, Valentina; Veyrat-Durebex, Christelle; Rigo, Dorothée; Fabbiano, Salvatore; Stevanović, Ana; Hagemann, Stefanie Claudia; Montet, Xavier; Seimbille, Yann; Zamboni, Nicola; Hapfelmeier, Siegfried Hektor; Trajkovski, Mirko (2015). Gut Microbiota Orchestrates Energy Homeostasis during Cold. Cell, 163(6), pp. 1360-1374. Cell Press 10.1016/j.cell.2015.11.004

	Text Cell 2015 Chevalier.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (4MB)
Preview	Text CELL-D-15-01010_R2r.pdf - Accepted Version Available under License Publisher holds Copyright. Download (6MB) | Preview

Microbial functions in the host physiology are a result of the microbiota-host co-evolution. We show that cold exposure leads to marked shift of the microbiota composition, referred to as cold microbiota. Transplantation of the cold microbiota to germ-free mice is sufficient to increase insulin sensitivity of the host and enable tolerance to cold partly by promoting the white fat browning, leading to increased energy expenditure and fat loss. During prolonged cold, however, the body weight loss is attenuated, caused by adaptive mechanisms maximizing caloric uptake and increasing intestinal, villi, and microvilli lengths. This increased absorptive surface is transferable with the cold microbiota, leading to altered intestinal gene expression promoting tissue remodeling and suppression of apoptosis-the effect diminished by co-transplanting the most cold-downregulated strain Akkermansia muciniphila during the cold microbiota transfer. Our results demonstrate the microbiota as a key factor orchestrating the overall energy homeostasis during increased demand.

Interest & Impact

Downloads

273 since deposited on 26 Apr 2016
9 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item