Local glucocorticoid production in the mouse lung is induced by immune cell stimulation

Hostettler, N; Bianchi, P; Gennari-Moser, C; Kassahn, D; Schoonjans, K; Corazza, N; Brunner, T (2012). Local glucocorticoid production in the mouse lung is induced by immune cell stimulation. Allergy, 67(2), pp. 227-34. Oxford: Wiley-Blackwell 10.1111/j.1398-9995.2011.02749.x

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Glucocorticoids (GC) are potent anti-inflammatory and immunosuppressive steroid hormones, mainly produced by the adrenal glands. However, increasing evidence supports the idea of additional extra-adrenal sources of bioactive GC. The lung epithelium is constantly exposed to a plethora of antigenic stimuli, and local GC synthesis could contribute to limit uncontrolled immune reactions and tissue damage.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Corazza, Nadia

ISSN:

0105-4538

Publisher:

Wiley-Blackwell

Language:

English

Submitter:

Factscience Import

Date Deposited:

04 Oct 2013 14:24

Last Modified:

17 Mar 2015 21:05

Publisher DOI:

10.1111/j.1398-9995.2011.02749.x

PubMed ID:

22111694

Web of Science ID:

000298982600012

URI:

https://boris.unibe.ch/id/eprint/8566 (FactScience: 214152)

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