Progress in imaging methods: insights gained into Plasmodium biology.

De Niz Hidalgo, Mariana Isabel; Burda, Paul-Christian; Kaiser, Gesine; Del Portillo, Hernando A; Spielmann, Tobias; Frischknecht, Freddy; Heussler, Volker (2017). Progress in imaging methods: insights gained into Plasmodium biology. Nature reviews. Microbiology, 15(1), pp. 37-54. Springer Nature 10.1038/nrmicro.2016.158

[img] Text
nrmicro.2016.158.pdf - Published Version
Restricted to registered users only
Available under License Publisher holds Copyright.

Download (2MB) | Request a copy

Over the past decade, major advances in imaging techniques have enhanced our understanding of Plasmodium spp. parasites and their interplay with mammalian hosts and mosquito vectors. Cryoelectron tomography, cryo-X-ray tomography and super-resolution microscopy have shifted paradigms of sporozoite and gametocyte structure, the process of erythrocyte invasion by merozoites, and the architecture of Maurer's clefts. Intravital time-lapse imaging has been revolutionary for our understanding of pre-erythrocytic stages of rodent Plasmodium parasites. Furthermore, high-speed imaging has revealed the link between sporozoite structure and motility, and improvements in time-lapse microscopy have enabled imaging of the entire Plasmodium falciparum erythrocytic cycle and the complete Plasmodium berghei pre-erythrocytic stages for the first time. In this Review, we discuss the contribution of key imaging tools to these and other discoveries in the malaria field over the past 10 years.

Item Type:

Journal Article (Review Article)

Division/Institute:

08 Faculty of Science > Department of Biology > Institute of Cell Biology
08 Faculty of Science > Department of Biology > Institute of Cell Biology > Malaria

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

De Niz Hidalgo, Mariana Isabel; Burda, Paul-Christian; Kaiser, Gesine and Heussler, Volker

Subjects:

500 Science > 570 Life sciences; biology

ISSN:

1740-1526

Publisher:

Springer Nature

Funders:

[UNSPECIFIED] SystemsX
[4] Swiss National Science Foundation

Language:

English

Submitter:

Volker Heussler

Date Deposited:

22 Dec 2016 16:23

Last Modified:

31 Jan 2019 08:54

Publisher DOI:

10.1038/nrmicro.2016.158

PubMed ID:

27890922

BORIS DOI:

10.7892/boris.91344

URI:

https://boris.unibe.ch/id/eprint/91344

Actions (login required)

Edit item Edit item
Provide Feedback