Hirschi, Stephan; Stauffer, Mirko; Harder, Daniel; Müller, Daniel J; Meier, Wolfgang; Fotiadis, Dimitrios José (2016). Engineering and Assembly of Protein Modules into Functional Molecular Systems. CHIMIA, 70(6), pp. 398-401. Schweizerische Chemische Gesellschaft 10.2533/chimia.2016.398
|
Text
Engineering and Assembly of Protein.pdf - Published Version Available under License Publisher holds Copyright. Download (250kB) | Preview |
Synthetic biology approaches range from the introduction of unique features into organisms to the assembly of isolated biomacromolecules or synthetic building blocks into artificial biological systems with biomimetic or completely novel functionalities. Simple molecular systems can be based on containers on the nanoscale that are equipped with tailored functional modules for various applications in healthcare, industry or biological and medical research. The concept, or vision, of assembling native or engineered proteins and/or synthetic components as functional modules into molecular systems is discussed. The main focus is laid on the engineering of energizing modules generating chemical energy, transport modules using this energy to translocate molecules between compartments of a molecular system, and catalytic modules (bio-)chemically processing the molecules. Further key aspects of this discourse are possible approaches for the assembly of simple nanofactories and their applications in biotechnology and medical health.
Item Type: |
Journal Article (Review Article) |
---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Hirschi, Stephan, Stauffer, Mirko, Harder, Daniel, Fotiadis, Dimitrios José |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
0009-4293 |
Publisher: |
Schweizerische Chemische Gesellschaft |
Language: |
English |
Submitter: |
Barbara Franziska Järmann-Bangerter |
Date Deposited: |
19 Apr 2017 10:19 |
Last Modified: |
05 Dec 2022 15:02 |
Publisher DOI: |
10.2533/chimia.2016.398 |
PubMed ID: |
27363367 |
BORIS DOI: |
10.7892/boris.94007 |
URI: |
https://boris.unibe.ch/id/eprint/94007 |