Alterations of the translation apparatus during aging and stress response

Gonskikh, Yulia; Polacek, Norbert (2017). Alterations of the translation apparatus during aging and stress response. Mechanisms of Ageing and Development, 168, pp. 30-36. Elsevier 10.1016/j.mad.2017.04.003

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Aging is a biological process characterized by the irreversible and time-dependent deterioration of cell functions, tissues, and organs. Accumulating studies in a wide range of species from yeast to human revealed changes associated with the aging process to be conserved throughout evolution. The main characteristics of aging are (i) genomic instability, (ii) loss of telomere function, (iii) epigenetic changes,(iv) increased cellular senescence, (v) depletion of the stem cell pool, (vi) altered intercellular communication and (vii) loss of protein homeostasis. Among the multiple molecular mechanisms underlying aging, alterations of the translation machinery affecting the rate and selectivity of protein biosynthesis seem to play a central role. At the very heart of translation is the ribosome, a multifaceted and universally conserved RNA-protein particle responsible for accurate polypeptide synthesis and co-translational protein folding. Here we summarize and discuss recent developments on the contribution of altered translation and age-dependent modifications on the ribosome structure to aging and cellular senescence.

Item Type:

Journal Article (Original Article)

Division/Institute:

08 Faculty of Science > Departement of Chemistry and Biochemistry

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Gonskikh, Yulia and Polacek, Norbert

Subjects:

500 Science > 570 Life sciences; biology
500 Science > 540 Chemistry

ISSN:

0047-6374

Publisher:

Elsevier

Language:

English

Submitter:

Christina Schüpbach

Date Deposited:

06 Jun 2017 16:09

Last Modified:

14 Dec 2017 01:30

Publisher DOI:

10.1016/j.mad.2017.04.003

BORIS DOI:

10.7892/boris.99604

URI:

https://boris.unibe.ch/id/eprint/99604

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