Gerbes, Alexander; Zoulim, Fabien; Tilg, Herbert; Dufour, Jean-François; Bruix, Jordi; Paradis, Valérie; Salem, Riad; Peck-Radosavljevic, Markus; Galle, Peter R; Greten, Tim F; Nault, Jean-Charles; Avila, Matias A (2018). Gut roundtable meeting paper: selected recent advances in hepatocellular carcinoma. Gut, 67(2), pp. 380-388. BMJ Publishing Group 10.1136/gutjnl-2017-315068
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Hepatocellular carcinoma (HCC) ranks number three among the most frequent causes of death from solid tumors worldwide. With obesity and fatty liver diseases as risk factors on the rise, HCC represents an ever increasing challenge. While there is still no curative treatment for most patients numerous novel drugs have been proposed, but most ultimately failed in phase III trials. This manuscript targets therapeutic advances and most burning issues. Expert key point summaries and urgent research agenda are provided regarding risk factors, including microbiota, need for prognostic and predictive biomarkers and the equivocal role of liver biopsy. Therapeutic topics highlighted are locoregional techniques, combination therapies and the potential of immunotherapy. Finally the manuscript provides a critical evaluation of novel targets and strategies for personalized treatment of HCC.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie |
UniBE Contributor: |
Dufour, Jean-François |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0017-5749 |
Publisher: |
BMJ Publishing Group |
Language: |
English |
Submitter: |
Thi Thao Anh Pham |
Date Deposited: |
06 Apr 2018 11:53 |
Last Modified: |
05 Dec 2022 15:09 |
Publisher DOI: |
10.1136/gutjnl-2017-315068 |
PubMed ID: |
29150490 |
Uncontrolled Keywords: |
clinical trials hepatocellular carcinoma |
BORIS DOI: |
10.7892/boris.108695 |
URI: |
https://boris.unibe.ch/id/eprint/108695 |
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