Wüthrich, Daniel; Boujon, Céline; Truchet, Laura Rosyne Hedwig; Selimovic-Hamza, Senija; Oevermann, Anna; Bouzalas, Ilias; Bruggmann, Rémy; Seuberlich, Torsten (2016). Exploring the virome of cattle with non-suppurative encephalitis of unknown etiology by metagenomics. Virology, 493, pp. 22-30. Academic Press 10.1016/j.virol.2016.03.009
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Non-suppurative encephalitis is one of the most frequent pathological diagnosis in cattle with neurological disease, but there is a gap in the knowledge on disease-associated pathogens. In order to identify viruses that are associated with non-suppurative encephalitis in cattle, we used a viral metagenomics approach on a sample set of 16 neurologically-diseased cows. We detected six virus candidates: parainfluenza virus 5 (PIV-5), bovine astrovirus CH13/NeuroS1 (BoAstV-CH13/NeuroS1), bovine polyomavirus 2 (BPyV-2 SF), ovine herpesvirus 2 (OvHV-2), bovine herpesvirus 6 (BHV-6) and a novel bovine betaretrovirus termed BoRV-CH15. In a case-control study using PCR, BoAstV-CH13 (p=0.046), BoPV-2 SF (p=0.005) and BoHV-6 (p=4.3E-05) were statistically associated with the disease. These data expand our knowledge on encephalitis-associated pathogens in cattle and point to the value of NGS in resolving complex infection scenarios in a clinical disease setting.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
05 Veterinary Medicine > Research Foci > NeuroCenter 05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Experimental Clinical Research 08 Faculty of Science > Department of Biology > Bioinformatics and Computational Biology |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Wüthrich, Daniel, Boujon, Céline, Truchet, Laura Rosyne Hedwig, Selimovic-Hamza, Senija, Oevermann, Anna, Bouzalas, Ilias, Bruggmann, Rémy, Seuberlich, Torsten |
Subjects: |
500 Science > 570 Life sciences; biology |
ISSN: |
0042-6822 |
Publisher: |
Academic Press |
Language: |
English |
Submitter: |
Torsten Seuberlich |
Date Deposited: |
07 Jun 2018 09:35 |
Last Modified: |
05 Dec 2022 15:14 |
Publisher DOI: |
10.1016/j.virol.2016.03.009 |
PubMed ID: |
26994586 |
BORIS DOI: |
10.7892/boris.117027 |
URI: |
https://boris.unibe.ch/id/eprint/117027 |
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