Functional Association between Regulatory RNAs and the Annexins.

Monastyrskaya-Stäuber, Katia (2018). Functional Association between Regulatory RNAs and the Annexins. International journal of molecular sciences, 19(2) MDPI 10.3390/ijms19020591

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Cells respond to pathophysiological states by activation of stress-induced signalling. Regulatory non-coding microRNAs (miRNAs) often form stable feed-forward loops which ensure prolongation of the signal, contributing to sustained activation. Members of the annexin protein family act as sensors for Ca, pH, and lipid second messengers, and regulate various signalling pathways. Recently, annexins were reported to participate in feedback loops, suppressing miRNA synthesis and attenuating stress-induced dysregulation of gene expression. They can directly or indirectly associate with RNAs, and are transferred between the cells in exosomes and shed microvesicles. The ability of annexins to recruit other proteins and miRNAs into exosomes implicates them in control of cell-cell interactions, affecting the adaptive responses and remodelling processes during disease. The studies summarized in this Review point to an emerging role of annexins in influencing the synthesis, localisation, and transfer of regulatory RNAs.

Item Type:

Journal Article (Review Article)

Division/Institute:

04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology

UniBE Contributor:

Monastyrskaya-Stäuber, Katia

Subjects:

600 Technology > 610 Medicine & health

ISSN:

1661-6596

Publisher:

MDPI

Language:

English

Submitter:

Laetitia Hayoz

Date Deposited:

05 Jul 2018 10:51

Last Modified:

07 Aug 2024 15:45

Publisher DOI:

10.3390/ijms19020591

PubMed ID:

29462943

Uncontrolled Keywords:

annexin exosome gene expression miRNA signalling

BORIS DOI:

10.7892/boris.118246

URI:

https://boris.unibe.ch/id/eprint/118246

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