Effects of isoflurane upon minimum alveolar concentration and cerebral cortex depression in pigs and goats: an interspecies comparison

Haga, H.A.; Ranheim, B.; Spadavecchia, C. (2011). Effects of isoflurane upon minimum alveolar concentration and cerebral cortex depression in pigs and goats: an interspecies comparison. Veterinary journal, 187(2), pp. 217-20. Amsterdam: Elsevier 10.1016/j.tvjl.2009.11.010

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This study compared the effects of isoflurane in pigs (n=10 Yorkshire-Landrace cross) and dairy goats (n=10) by evaluation of electroencephalographic (EEG) burst suppression thresholds (BST) in the cerebral cortex and minimum alveolar concentration (MAC) values in the spinal cord. The study also investigated whether individual MAC values can predict the effects of isoflurane on the cerebral cortex. MAC values and BST/MAC ratios were significantly different between species. Inhibition of movement by isoflurane may be less effective in pigs than in goats. No significant correlation was found between individual MAC and BST values, indicating that in single animals the individual MAC poorly reflects the cerebrocortical depressant effect of isoflurane in pigs and goats.

Item Type:	Journal Article (Original Article)
Division/Institute:	05 Veterinary Medicine > Department of Clinical Veterinary Medicine (DKV) > DKV - Anaesthesiology
UniBE Contributor:	Spadavecchia, Claudia
ISSN:	1090-0233
Publisher:	Elsevier
Language:	English
Submitter:	Factscience Import
Date Deposited:	04 Oct 2013 14:31
Last Modified:	05 Dec 2022 14:10
Publisher DOI:	10.1016/j.tvjl.2009.11.010
Web of Science ID:	000288520000015
URI:	https://boris.unibe.ch/id/eprint/12053 (FactScience: 218328)