Ventilation and perfusion assessed by functional MRI in children with CF: reproducibility in comparison to lung function.

Nyilas, Sylvia Meryl; Bauman, Grzegorz; Pusterla, Orso; Ramsey, Kathryn Angela; Singer, Florian; Stranzinger, Enno; Yammine, Sophie; Casaulta, Carmen; Bieri, Oliver; Latzin, Philipp (2019). Ventilation and perfusion assessed by functional MRI in children with CF: reproducibility in comparison to lung function. Journal of cystic fibrosis, 18(4), pp. 543-550. Elsevier 10.1016/j.jcf.2018.10.003

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BACKGROUND

Chronic lung diseases such as cystic fibrosis (CF) can be monitored by imaging and lung function modalities. Magnetic resonance imaging (MRI) techniques such as matrix pencil (MP) decomposition allows for evaluation of regional impairment of fractional ventilation (R) and relative perfusion (R). However, reproducibility of MP MRI outcomes in children with CF is unknown. We examined short-term variability of ventilation and perfusion impairment from MP MRI and compared this to lung function outcomes.

METHOD

Twenty-threeCF and 12 healthy school-aged children underwent MRI and lung function tests on the same day on two occasions 24 h apart. Global ventilation inhomogeneity was assessed by the lung clearance index (LCI) from nitrogen-multiple breath washout (N-MBW) technique. Intra-class-coefficient (ICC), percentage change, and Bland-Altman limits of agreement were evaluated to assess reproducibility.

RESULTS

Sixty-nine measurements from MP MRI and N-MBW were performed. The ICC between two visits for R, R and LCI ranged between 0.60 and 0.90 in individuals with CF and healthy controls. In individuals with CF, percentage of change between the visits was 0.02% for R, -1.11% for R and 2.91% for LCI and limits of agreement between visits were - 4.3% and 3.9% for R, -4.4% and 3.7% for R, and -2.6 and 3.0 for LCI.

CONCLUSIONS

Functional imaging is reproducible and short-term changes in R and R greater than ±4.4% can be considered clinical meaningful. Very good short-term reproducibility, and easy application without the need for breathing maneuvers or contrast agent, makes MP MRI a promising surveillance method for CF.

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