Emerging non-invasive approaches for diagnosis and monitoring of portal hypertension.

Qi, Xiaolong; Berzigotti, Annalisa; Cardenas, Andres; Sarin, Shiv Kumar (2018). Emerging non-invasive approaches for diagnosis and monitoring of portal hypertension. The lancet. Gastroenterology & hepatology, 3(10), pp. 708-719. Elsevier 10.1016/S2468-1253(18)30232-2

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Clinically significant portal hypertension is associated with an increased risk of developing gastro-oesophageal varices and hepatic decompensation. Hepatic venous pressure gradient measurement and oesophagogastroduodenoscopy are the gold-standard methods for assessing clinically significant portal hypertension (hepatic venous pressure gradient ≥10 mm Hg) and gastro-oesophageal varices, respectively. However, invasiveness, cost, and feasibility limit their widespread use, especially if repeated and serial evaluations are required to assess the efficacy of pharmacotherapy. Although new techniques for non-invasive portal pressure measurement have been pursued for many decades, only recently have new tools been assessed and validated for larger clinical application. This Review focuses on the recent advances in non-invasive approaches for the diagnosis and serial monitoring of portal hypertension and varices for clinical practice.

Item Type:	Journal Article (Review Article)
Division/Institute:	04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie 04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
UniBE Contributor:	Berzigotti, Annalisa
Subjects:	600 Technology > 610 Medicine & health
ISSN:	2468-1253
Publisher:	Elsevier
Language:	English
Submitter:	Thi Thao Anh Pham
Date Deposited:	17 Dec 2018 08:30
Last Modified:	05 Dec 2022 15:21
Publisher DOI:	10.1016/S2468-1253(18)30232-2
PubMed ID:	30215362
URI:	https://boris.unibe.ch/id/eprint/122091