Ebert, Matthias P A; Tänzer, Marc; Balluff, Benjamin; Burgermeister, Elke; Kretzschmar, Antje Karen; Hughes, David J; Tetzner, Reimo; Lofton-Day, Catherine; Rosenberg, Robert; Reinacher-Schick, Anke C; Schulmann, Karsten; Tannapfel, Andrea; Hofheinz, Ralf; Röcken, Christoph; Keller, Gisela; Langer, Rupert; Specht, Katja; Porschen, Rainer; Stöhlmacher-Williams, Jan; Schuster, Tibor; ... (2012). TFAP2E-DKK4 and chemoresistance in colorectal cancer. New England journal of medicine NEJM, 366(1), pp. 44-53. Waltham, Mass.: Massachusetts Medical Society MMS 10.1056/NEJMoa1009473
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Chemotherapy for advanced colorectal cancer leads to improved survival; however, predictors of response to systemic treatment are not available. Genomic and epigenetic alterations of the gene encoding transcription factor AP-2 epsilon (TFAP2E) are common in human cancers. The gene encoding dickkopf homolog 4 protein (DKK4) is a potential downstream target of TFAP2E and has been implicated in chemotherapy resistance. We aimed to further evaluate the role of TFAP2E and DKK4 as predictors of the response of colorectal cancer to chemotherapy.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology |
UniBE Contributor: |
Langer, Rupert |
ISSN: |
0028-4793 |
Publisher: |
Massachusetts Medical Society MMS |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:32 |
Last Modified: |
05 Dec 2022 14:10 |
Publisher DOI: |
10.1056/NEJMoa1009473 |
PubMed ID: |
22216841 |
Web of Science ID: |
000299968800006 |
BORIS DOI: |
10.7892/boris.12527 |
URI: |
https://boris.unibe.ch/id/eprint/12527 (FactScience: 218881) |
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