MicroRNAs as modulators of T cell functions in cancer.

Emming, Stefan; Chirichella, Michele; Monticelli, Silvia (2018). MicroRNAs as modulators of T cell functions in cancer. Cancer letters, 430, pp. 172-178. Elsevier 10.1016/j.canlet.2018.05.019

Text 1-s2.0-S0304383518303446-main.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (585kB)

MicroRNAs (miRNAs) are short RNA molecules that regulate gene expression post-transcriptionally. They have emerged as important modulators of T lymphocyte biology, influencing cell activation, differentiation and proliferation in response to environmental signals. Here, we will discuss how miRNAs expressed by T cells can influence two key aspects of tumorigenesis, namely the direct, cell-intrinsic oncogenic transformation of T lymphocytes, as well as the indirect effects on tumor growth mediated by altered immune surveillance. We will specifically focus on three miRNAs that have been shown to regulate different aspects of T cell biology in both physiological and pathological conditions, namely miR-155, miR-146a and miR-181a. We aim at providing examples of the fundamental importance of miRNA-regulated networks in determining the fate of T lymphocytes during oncogenic transformation and in the control of tumor growth.

Interest & Impact

Downloads

1 since deposited on 07 May 2019
0 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item