Crohn's disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy

Scharl, Michael; Mwinyi, Jessica; Fischbeck, Anne; Leucht, Katharina; Eloranta, Jyrki J; Arikkat, Joba; Pesch, Theresa; Kellermeier, Silvia; Mair, Alma; Kullak-Ublick, Gerd A; Truninger, Kaspar; Noreen, Faiza; Regula, Jaroslaw; Gaj, Pawel; Pittet, Valerie; Mueller, Christoph; Hofmann, Claudia; Fried, Michael; McCole, Declan F and Rogler, Gerhard (2012). Crohn's disease-associated polymorphism within the PTPN2 gene affects muramyl-dipeptide-induced cytokine secretion and autophagy. Inflammatory bowel diseases, 18(5), pp. 900-12. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1002/ibd.21913

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The single nucleotide polymorphism (SNP) rs2542151 within the gene locus region encoding protein tyrosine phosphatase non-receptor type 2 (PTPN2) has been associated with Crohn's disease (CD), ulcerative colitis (UC), type-I diabetes, and rheumatoid arthritis. We have previously shown that PTPN2 regulates mitogen-activated protein kinase (MAPK) signaling and cytokine secretion in human THP-1 monocytes and intestinal epithelial cells (IEC). Here, we studied whether intronic PTPN2 SNP rs1893217 regulates immune responses to the nucleotide-oligomerization domain 2 (NOD2) ligand, muramyl-dipeptide (MDP).

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