Osawa, Eduardo Atsushi; Cutuli, Salvatore Lucio; Bitker, Laurent; Canet, Emmanuel; Cioccari, Luca; Iguchi, Naoya; Lankadeva, Yugeesh R; Eastwood, Glenn M; Evans, Roger G; May, Clive N; Bellomo, Rinaldo (2019). Effect of Furosemide on Urinary Oxygenation in Patients with Septic Shock. Blood purification, 48(4), pp. 336-345. Karger 10.1159/000501512
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BACKGROUND
Renal medullary hypoxia precedes the development of acute kidney injury in experimental sepsis and can now be assessed by continuous measurement of urinary oxygen tension (PuO2).
OBJECTIVES
We aimed to test if PuO2 measurements in patients with septic shock would be similar to those shown in experimental sepsis and would detect changes induced by the administration of furosemide.
METHOD
Pilot prospective observational cohort study in a tertiary intensive care unit (ICU). Seven adult patients with septic shock admitted to ICU had PuO2 measurements recorded minutely. There were 29 episodes of intravenous furosemide (20 mg n = 19; 40 mg n = 10).
RESULTS
The median pre-furosemide PuO2 was low at 21.2 mm Hg (interquartile range [IQR] 17.73-24.86) and increased to 26 mm Hg (IQR 20.27-29.95) at 20 min (p < 0.01), to 27.5 mm Hg (IQR 24.06-33.18) at 40 min (p < 0.01) and to 28.5 mm Hg (IQR 22.65-31.03) at 60 min (p < 0.01). The increase in PuO2 was greater in episodes with a diuretic response >2 mL/kg/h than during episodes without such a response (p < 0.01).
CONCLUSIONS
PuO2 measurements in patients are reflective of the low values reported in experimental models of sepsis. PuO2 values increased following furosemide administration with a response independently associated with greater diuresis.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care |
UniBE Contributor: |
Cioccari, Luca (A) |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
0253-5068 |
Publisher: |
Karger |
Language: |
English |
Submitter: |
Mirella Aeberhard |
Date Deposited: |
22 Aug 2019 10:33 |
Last Modified: |
24 May 2023 19:49 |
Publisher DOI: |
10.1159/000501512 |
PubMed ID: |
31336370 |
Uncontrolled Keywords: |
Furosemide Medullary oxygenation Sepsis Septic shock Urinary output Urinary oxygenation |
BORIS DOI: |
10.48350/132185 |
URI: |
https://boris.unibe.ch/id/eprint/132185 |
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