Wiesli, Peter; Pavlicek, Vojtech; Brändle, Michael; Pfammatter, Thomas; Perren, Aurel; Schmid, Christoph (2019). Distinct mechanisms of hypoglycaemia in patients with somatostatin-secreting neuroendocrine tumours. Endocrinology, diabetes & metabolism, 2(4), e00083. Wiley 10.1002/edm2.83
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Introduction
Somatostatin-secreting neuroendocrine tumours may present with diabetes, cholelithiasis and steatorrhoea. In addition, hypoglycaemia has been associated with somatostatinomas. However, the mechanism of hypoglycaemia in patients with somatostatinomas has not been well characterized.
Methods
We describe two patients with recurrent neuroglycopenic episodes caused by somatostatin-secreting neuroendocrine tumours in the liver, detected by abdominal CTs and whole-body octreotide scintigraphy scans and confirmed by biopsy.
Results
Pancreatic islet hyperplasia and co-secretion of insulin (in addition to somatostatin) from tumour cells, respectively, have been characterized as completely distinct mechanisms of hypoglycaemia at both the functional and morphological levels in these two patients.
Conclusions
Hypoglycaemia may be caused by different mechanisms in patients with somatostatinomas.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology |
UniBE Contributor: |
Perren, Aurel |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
2398-9238 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Aurel Perren |
Date Deposited: |
13 Nov 2019 15:58 |
Last Modified: |
29 Apr 2023 13:53 |
Publisher DOI: |
10.1002/edm2.83 |
PubMed ID: |
31592116 |
Uncontrolled Keywords: |
hyperinsulinaemia hypoglycaemia neuroendocrine tumour somatostatinoma |
BORIS DOI: |
10.7892/boris.134733 |
URI: |
https://boris.unibe.ch/id/eprint/134733 |
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