Bonollo, Francesco; Thalmann, George; Kruithof-de Julio, Marianna; Karkampouna, Sofia (2020). The Role of Cancer-Associated Fibroblasts in Prostate Cancer Tumorigenesis. Cancers, 12(7) MDPI AG 10.3390/cancers12071887
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Tumors strongly depend on their surrounding tumor microenvironment (TME) for growth and progression, since stromal elements are required to generate the optimal conditions for cancer cell proliferation, invasion, and possibly metastasis. Prostate cancer (PCa), though easily curable during primary stages, represents a clinical challenge in advanced stages because of the acquisition of resistance to anti-cancer treatments, especially androgen-deprivation therapies (ADT), which possibly lead to uncurable metastases such as those affecting the bone. An increasing number of studies is giving evidence that prostate TME components, especially cancer-associated fibroblasts (CAFs), which are the most abundant cell type, play a causal role in PCa since the very early disease stages, influencing therapy resistance and metastatic progression. This is highlighted by the prognostic value of the analysis of stromal markers, which may predict disease recurrence and metastasis. However, further investigations on the molecular mechanisms of tumor-stroma interactions are still needed to develop novel therapeutic approaches targeting stromal components. In this review, we report the current knowledge of the characteristics and functions of the stroma in prostate tumorigenesis, including relevant discussion of normal prostate homeostasis, chronic inflammatory conditions, pre-neoplastic lesions, and primary and metastatic tumors. Specifically, we focus on the role of CAFs, to point out their prognostic and therapeutic potential in PCa.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Urologie 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Urologie 04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Urology |
UniBE Contributor: |
Thalmann, George, Kruithof-de Julio, Marianna, Karkampouna, Sofia |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2072-6694 |
Publisher: |
MDPI AG |
Language: |
English |
Submitter: |
Jeannine Wiemann |
Date Deposited: |
04 Aug 2020 08:01 |
Last Modified: |
05 Dec 2022 15:39 |
Publisher DOI: |
10.3390/cancers12071887 |
PubMed ID: |
32668821 |
Uncontrolled Keywords: |
bone metastasis cancer associated fibroblasts prostate cancer reactive stroma tumor microenvironment |
BORIS DOI: |
10.7892/boris.145532 |
URI: |
https://boris.unibe.ch/id/eprint/145532 |
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