Maltecca, C.; Tiezzi, F.; Cole, J. B.; Baes, C. (2020). Symposium review: Exploiting homozygosity in the era of genomics-Selection, inbreeding, and mating programs. Journal of dairy science, 103(6), pp. 5302-5313. American Dairy Science Association 10.3168/jds.2019-17846
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The advent of genomic selection paved the way for an unprecedented acceleration in genetic progress. The increased ability to select superior individuals has been coupled with a drastic reduction in the generation interval for most dairy populations, representing both an opportunity and a challenge. Homozygosity is now rapidly accumulating in dairy populations. Currently, inbreeding depression is managed mostly by culling at the farm level and by controlling the overall accumulation of homozygosity at the population level. A better understanding of how homozygosity and recessive load are related will guarantee continued genetic improvement while curtailing the accumulation of harmful recessives and maintaining enough genetic variability to ensure the possibility of selection in the face of changing environmental conditions. In this review, we present a snapshot of the current dairy selection structure as it relates to response to selection and accumulation of homozygosity, briefly outline the main approaches currently used to manage inbreeding and overall variability, and present some approaches that can be used in the short term to control accumulation of harmful recessives while maintaining sustained selection pressure.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics 05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) |
UniBE Contributor: |
Baes, Christine Francoise |
Subjects: |
500 Science > 590 Animals (Zoology) 600 Technology > 630 Agriculture |
ISSN: |
0022-0302 |
Publisher: |
American Dairy Science Association |
Language: |
English |
Submitter: |
Christine Francoise Baes |
Date Deposited: |
05 Aug 2020 08:32 |
Last Modified: |
05 Dec 2022 15:39 |
Publisher DOI: |
10.3168/jds.2019-17846 |
PubMed ID: |
32331889 |
Uncontrolled Keywords: |
genomic evaluation inbreeding mating |
BORIS DOI: |
10.7892/boris.145581 |
URI: |
https://boris.unibe.ch/id/eprint/145581 |
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