Sinkala, Edford; Vinikoor, Michael; Miyanda Siyunda, Alice; Zyambo, Kanekwa; Besa, Ellen; Nsokolo, Bright; Wandeler, Gilles; Foster, Graham R; Kelly, Paul (2020). Hepatosplenic schistosomiasis in Zambian adults is characterized by increased liver stiffness: A nested case-control study. Heliyon, 6(7), e04534. Elsevier 10.1016/j.heliyon.2020.e04534
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Cirrhosis commonly complicates portal hypertension worldwide but in Zambia hepatosplenic schistosomiasis (HSS) dominates as the cause of portal hypertension. We need easier and non-invasive ways to assess HSS. Transient elastography (TE), a measure of liver stiffness can diagnose liver cirrhosis. TE remains unexplored in HSS patients, who generally have normal liver parenchyma. We aimed to explore liver stiffness in HSS. This nested case control study was conducted at the University Teaching Hospital, Lusaka, Zambia between January 2015 and January 2016. We enrolled 48 adults with HSS and 22 healthy controls. We assessed liver stiffness using TE while plasma hyaluronan was used to assess liver fibrosis. Plasma tumor necrosis factor receptor 1 (TNFR1) and soluble cluster of differentiation 14 (sCD14) were used to assess inflammation. The median (interquartile range) liver stiffness was higher in patients, 9.5 kPa (7.8, 12.8) than in controls, 4.7 kPa (4.0, 5.4), P < 0.0001. We noted linear correlations of hyaluronan and TNFR1 with the liver stiffness, P = 0.0307 and P = 0.0003 respectively. HSS patients seem to have higher liver stiffness than healthy controls. TE may be useful in identifying fibrosis in HSS. The positive correlations of inflammatory markers with TE suggest that HSS has both periportal and parenchymal pathophysiology.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) 04 Faculty of Medicine > Department of Haematology, Oncology, Infectious Diseases, Laboratory Medicine and Hospital Pharmacy (DOLS) > Clinic of Infectiology |
UniBE Contributor: |
Wandeler, Gilles |
Subjects: |
300 Social sciences, sociology & anthropology > 360 Social problems & social services 600 Technology > 610 Medicine & health |
ISSN: |
2405-8440 |
Publisher: |
Elsevier |
Funders: |
[42] Schweizerischer Nationalfonds ; [4] Swiss National Science Foundation |
Language: |
English |
Submitter: |
Annelies Luginbühl |
Date Deposited: |
18 Aug 2020 13:17 |
Last Modified: |
05 Dec 2022 15:40 |
Publisher DOI: |
10.1016/j.heliyon.2020.e04534 |
PubMed ID: |
32760834 |
Uncontrolled Keywords: |
Fibrosis Hepatosplenic schistosomiasis Liver stiffness Metabolism |
BORIS DOI: |
10.7892/boris.145778 |
URI: |
https://boris.unibe.ch/id/eprint/145778 |
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