Stein, Marco; Middendorp, Simon J; Carta, Valentina; Pejo, Ervin; Raines, Douglas E; Forman, Stuart A; Sigel, Erwin; Trauner, Dirk (2012). Azo-propofols: photochromic potentiators of GABA(A) receptors. Angewandte Chemie (International ed.), 51(42), pp. 10500-4. Weinheim: Wiley-VCH 10.1002/anie.201205475
Full text not available from this repository.Shine and rise! GABA(A) receptors are ligand-gated chloride ion channels that respond to γ-aminobutyric acid (GABA), which is the major inhibitory neurotransmitter of the mammalian central nervous system. Azobenzene derivatives of propofol, such as compound 1 (see scheme), increase GABA-induced currents in the dark form and lose this property upon light exposure and thus function as photochromic potentiators. Compound 1 can be employed as a light-dependent general anesthetic in translucent tadpoles.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Biochemistry and Molecular Medicine |
UniBE Contributor: |
Middendorp, Simon, Carta, Valentina, Sigel, Erwin |
ISSN: |
1433-7851 |
Publisher: |
Wiley-VCH |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:37 |
Last Modified: |
05 Dec 2022 14:11 |
Publisher DOI: |
10.1002/anie.201205475 |
PubMed ID: |
22968919 |
Web of Science ID: |
000309745600011 |
URI: |
https://boris.unibe.ch/id/eprint/15040 (FactScience: 222194) |
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