Most frequent South Asian haplotypes of ACE2 share identity by descent with East Eurasian populations

Srivastava, Anshika; Pandey, Rudra Kumar; Singh, Prajjval Pratap; Kumar, Pramod; Rasalkar, Avinash Arvind; Tamang, Rakesh; van Driem, George; Shrivastava, Pankaj; Chaubey, Gyaneshwer (2020). Most frequent South Asian haplotypes of ACE2 share identity by descent with East Eurasian populations. PLoS ONE, 15(9), e0238255. Public Library of Science 10.1371/journal.pone.0238255

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It was shown that the human Angiotensin-converting enzyme 2 (ACE2) is the receptor of recent coronavirus SARS-CoV-2, and variation in this gene may affect the susceptibility of a population. Therefore, we have analysed the sequence data of ACE2 among 393 samples worldwide, focusing on South Asia. Genetically, South Asians are more related to West Eurasian populations rather than to East Eurasians. In the present analyses of ACE2, we observed that the majority of South Asian haplotypes are closer to East Eurasians rather than to West Eurasians. The phylogenetic analysis suggested that the South Asian haplotypes shared with East Eurasians involved two unique event polymorphisms (rs4646120 and rs2285666). In contrast with the European/American populations, both of the SNPs have largely similar frequencies for East Eurasians and South Asians, Therefore, it is likely that among the South Asians, host susceptibility to the novel coronavirus SARS-CoV-2 will be more similar to that of East Eurasians rather than to that of Europeans.

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