Duhan, Vikas; Khairnar, Vishal; Kitanovski, Simo; Hamdan, Thamer A; Klein, Andrés D; Lang, Judith; Ali, Murtaza; Adomati, Tom; Bhat, Hilal; Friedrich, Sarah-Kim; Li, Fanghui; Krebs, Philippe; Futerman, Anthony H; Addo, Marylyn M; Hardt, Cornelia; Hoffmann, Daniel; Lang, Philipp A; Lang, Karl S (2021). Integrin Alpha E (CD103) Limits Virus-Induced IFN-I Production in Conventional Dendritic Cells. Frontiers in immunology, 11, p. 607889. Frontiers Research Foundation 10.3389/fimmu.2020.607889
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Early and strong production of IFN-I by dendritic cells is important to control vesicular stomatitis virus (VSV), however mechanisms which explain this cell-type specific innate immune activation remain to be defined. Here, using a genome wide association study (GWAS), we identified Integrin alpha-E (Itgae, CD103) as a new regulator of antiviral IFN-I production in a mouse model of vesicular stomatitis virus (VSV) infection. CD103 was specifically expressed by splenic conventional dendritic cells (cDCs) and limited IFN-I production in these cells during VSV infection. Mechanistically, CD103 suppressed AKT phosphorylation and mTOR activation in DCs. Deficiency in CD103 accelerated early IFN-I in cDCs and prevented death in VSV infected animals. In conclusion, CD103 participates in regulation of cDC specific IFN-I induction and thereby influences immune activation after VSV infection.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute of Pathology > Immunopathology |
UniBE Contributor: |
Krebs, Philippe |
Subjects: |
500 Science > 570 Life sciences; biology |
ISSN: |
1664-3224 |
Publisher: |
Frontiers Research Foundation |
Language: |
English |
Submitter: |
Philippe Krebs |
Date Deposited: |
17 Feb 2021 09:23 |
Last Modified: |
05 Dec 2022 15:47 |
Publisher DOI: |
10.3389/fimmu.2020.607889 |
PubMed ID: |
33584680 |
Uncontrolled Keywords: |
AKT CD103 GWAS IFN-I Itgae genome wide association screen mTOR vesicular stomatitis virus |
BORIS DOI: |
10.48350/152257 |
URI: |
https://boris.unibe.ch/id/eprint/152257 |
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