Calcium transfer between endoplasmic reticulum and mitochondria in liver diseases.

Jin, Chaonan; Kumar, Pavitra; Gracia-Sancho, Jorge; Dufour, Jean-François (2021). Calcium transfer between endoplasmic reticulum and mitochondria in liver diseases. FEBS letters, 595(10), pp. 1411-1421. FEBS Press 10.1002/1873-3468.14078

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Calcium (Ca2+ ) is a second messenger essential for cellular homeostasis. Inside the cell, Ca2+ is compartmentalized and exchanged among organelles in response to both external and internal stimuli. Mitochondria-associated membranes (MAMs) provide a platform for proteins and channels involved in Ca2+ transfer between the endoplasmic reticulum (ER) and mitochondria. Deregulated Ca2+ signaling and proteins regulating ER-mitochondria interactions have been linked to liver diseases and intensively investigated in recent years. In this review, we summarize the role of MAM-resident proteins in Ca2+ transfer and their association with different liver diseases.

Item Type:

 Journal Article (Review Article)

Division/Institute:

 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > DBMR Forschung Mu35 > Forschungsgruppe Hepatologie
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR)

UniBE Contributor:

 Jin, Chaonan, Kumar, Pavitra, Gracia Sancho, Jorge Sergio, Dufour, Jean-François

Subjects:

 600 Technology > 610 Medicine & health

ISSN:

 1873-3468

Publisher:

 FEBS Press

Language:

 English

Submitter:

 Rahel Fuhrer

Date Deposited:

 12 May 2021 11:30

Last Modified:

 05 Dec 2022 15:50

Publisher DOI:

 10.1002/1873-3468.14078

PubMed ID:

 33752262

Uncontrolled Keywords:

 calcium transfer endoplasmic reticulum liver diseases mitochondria mitochondria-associated membranes

BORIS DOI:

 10.48350/155774

URI:

 https://boris.unibe.ch/id/eprint/155774

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