De Pretto, Michael; Mouthon, Michael; Debove, Ines; Pollo, Claudio; Schüpbach, Michael; Spierer, Lucas; Accolla, Ettore A. (2021). Proactive inhibition is not modified by deep brain stimulation for Parkinson's disease: An electrical neuroimaging study. Human brain mapping, 42(12), pp. 3934-3949. Wiley-Blackwell 10.1002/hbm.25530
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In predictable contexts, motor inhibitory control can be deployed before the actual need for response suppression. The brain functional underpinnings of proactive inhibition, and notably the role of basal ganglia, are not entirely identified. We investigated the effects of deep brain stimulation of the subthalamic nucleus or internal globus pallidus on proactive inhibition in patients with Parkinson's disease. They completed a cued go/no-go proactive inhibition task ON and (unilateral) OFF stimulation while EEG was recorded. We found no behavioural effect of either subthalamic nucleus or internal globus pallidus deep brain stimulation on proactive inhibition, despite a general improvement of motor performance with subthalamic nucleus stimulation. In the non-operated and subthalamic nucleus group, we identified periods of topographic EEG modulation by the level of proactive inhibition. In the subthalamic nucleus group, source estimation analysis suggested the initial involvement of bilateral frontal and occipital areas, followed by a right lateralized fronto-basal network, and finally of right premotor and left parietal regions. Our results confirm the overall preservation of proactive inhibition capacities in both subthalamic nucleus and internal globus pallidus deep brain stimulation, and suggest a partly segregated network for proactive inhibition, with a preferential recruitment of the indirect pathway.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurology 04 Faculty of Medicine > Department of Head Organs and Neurology (DKNS) > Clinic of Neurosurgery |
UniBE Contributor: |
Debove, Ines, Pollo, Claudio, Schüpbach, Michael |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1065-9471 |
Publisher: |
Wiley-Blackwell |
Language: |
English |
Submitter: |
Nicole Söll |
Date Deposited: |
14 Jul 2021 14:05 |
Last Modified: |
05 Dec 2022 15:52 |
Publisher DOI: |
10.1002/hbm.25530 |
PubMed ID: |
34110074 |
Uncontrolled Keywords: |
EEG indirect pathway inhibitory control internal globus pallidus subthalamic nucleus |
BORIS DOI: |
10.48350/157494 |
URI: |
https://boris.unibe.ch/id/eprint/157494 |
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