Lange, Naomi F.; Radu, Pompilia; Dufour, Jean-François (2021). Prevention of NAFLD-associated HCC: role of lifestyle and chemoprevention. Journal of hepatology, 75(5), pp. 1217-1227. Elsevier 10.1016/j.jhep.2021.07.025
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1-s2.0-S0168827821019541-main.pdf - Accepted Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (7MB) | Preview |
In many countries worldwide, the burden of hepatocellular carcinoma (HCC) in non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) is increasing and preventive strategies are needed to counteract this trend. This review provides an overview of the evidence on preventive strategies in NAFLD-associated HCC. We considered the impact of lifestyle factors such as weight loss, physical activity, smoking, dietary patterns and food items, including coffee and alcohol, on both HCC and NAFLD/NASH. Furthermore, evidence on chemopreventive treatments, including aspirin, anti-diabetic treatments and statins is summarized. The role of adjuvant therapies considered for tertiary prevention of HCC is briefly reviewed.
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