Persistent hyperammonia and altered concentrations of urea cycle metabolites in a 5-day swine experiment of sepsis.

Ferrario, Manuela; Pastorelli, Roberta; Brunelli, Laura; Liu, Shengchen; Zanella do Amaral Campos, Pedro Paulo; Casoni, Daniela; Z'Graggen, Werner J; Jakob, Stephan M (2021). Persistent hyperammonia and altered concentrations of urea cycle metabolites in a 5-day swine experiment of sepsis. Scientific reports, 11(1), p. 18430. Springer Nature 10.1038/s41598-021-97855-7

Preview

Text s41598-021-97855-7.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (3MB) | Preview

We measured plasma and cerebrospinal fluid (CSF) metabolite concentrations in a 5-day porcine sepsis model of fecal peritonitis. The objectives were: (i) to verify whether the expected pathways that had emerged in previous studies pertain only to the early inflammatory response or persist for the subsequent days; (ii) to identify metabolic derangements that arise later; (iii) to verify whether CSF metabolite concentrations were altered and if these alterations were similar to those in the blood or delayed. We observed an early response to inflammation and cytokine storms with alterations in lipid and glucose metabolism. The arginine/asymmetric dimethylarginine (ADMA) and phenylalanine/tyrosine balances changed 24 h after resuscitation in plasma, and later in CSF. There was a rise in ammonia concentration, with altered concentrations of metabolites in the urea cycle. Whether persistent derangement of these pathways have a role not only on short-term outcomes but also on longer-term comorbidities, such as septic encephalopathy, should be addressed in further studies.

Interest & Impact

Downloads

54 since deposited on 08 Nov 2021
12 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item