T-cell trafficking in the central nervous system

Sallusto, Federica; Impellizzieri, Daniela; Basso, Camilla; Laroni, Alice; Uccelli, Antonio; Lanzavecchia, Antonio; Engelhardt, Britta (2012). T-cell trafficking in the central nervous system. Immunological reviews, 248(1), pp. 216-27. Oxford: Wiley-Blackwell 10.1111/j.1600-065X.2012.01140.x

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To perform their distinct effector functions, pathogen-specific T cells have to migrate to target tissue where they recognize antigens and produce cytokines that elicit appropriate types of protective responses. Similarly, migration of pathogenic self-reactive T cells to target organs is an essential step required for tissue-specific autoimmunity. In this article, we review data from our laboratory as well as other laboratories that have established that effector function and migratory capacity are coordinately regulated in different T-cell subsets. We then describe how pathogenic T cells can enter into intact or inflamed central nervous system (CNS) to cause experimental autoimmune encephalomyelitis or multiple sclerosis. In particular, we elaborate on the role of CCR6/CCL20 axis in migration through the choroid plexus and the involvement of this pathway in immune surveillance of and autoimmunity in the CNS.

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