Ferrillo, Martina; Migliario, Mario; Roccuzzo, Andrea; Molinero-Mourelle, Pedro; Falcicchio, Giovanni; Umano, Giuseppina Rosaria; Pezzotti, Federica; Foglio Bonda, Pier Luigi; Calafiore, Dario; de Sire, Alessandro (2021). Periodontal Disease and Vitamin D Deficiency in Pregnant Women: Which Correlation with Preterm and Low-Weight Birth? Journal of clinical medicine, 10(19) MDPI 10.3390/jcm10194578
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Periodontal disease seems to be correlated with low vitamin D serum levels, preterm birth (PTB) and low birth weight (LBW), although the literature still lacks a consensus. This study aimed to investigate this correlation in a cohort of pregnant women over 20 weeks of gestation from the University Hospital "Maggiore della Carità", Novara, Italy. We assessed serum levels of vitamin D and oral health status through the following indexes: Oral Hygiene Index (OHI), Plaque Control Record (PCR), Gingival Bleeding Index (GBI), and Community Periodontal Index of Treatment Needs (CPTIN). Moreover, we assessed the number of PTB and LBW among the newborns. Out of 121 pregnant women recruited, 72 (mean age 29.91 ± 3.64 years) were included. There was a statistically significant correlation between preterm and OHI > 3 (p = 0.033), and between LBW and OHI > 3 (p = 0.005) and CPITN = 3 (p = 0.027). Both pregnant women with vitamin D deficiency ((25-hydroxy-vitamin D) < 30 ng/mL) and PTB plus LBW newborns were significantly correlated (p < 0.05) with poor levels of all oral health status indexes during pregnancy. Furthermore, these conditions (women with hypovitaminosis D and combination of PTB and LBW) were shown to be significantly correlated (p < 0.001). Taken together, our findings reported a high prevalence of PTB and LBW with poor oral health and vitamin D deficiency in pregnant women.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > School of Dental Medicine > Department of Periodontology 04 Faculty of Medicine > School of Dental Medicine > Department of Reconstructive Dentistry and Gerodontology |
UniBE Contributor: |
Roccuzzo, Andrea, Molinero Mourelle, Pedro |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2077-0383 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Lena Augé |
Date Deposited: |
24 Nov 2021 07:01 |
Last Modified: |
17 Jan 2023 13:55 |
Publisher DOI: |
10.3390/jcm10194578 |
PubMed ID: |
34640596 |
Uncontrolled Keywords: |
low birth weight oral hygiene periodontal disease pregnancy preterm birth vitamin D vitamin D deficiency |
BORIS DOI: |
10.48350/161344 |
URI: |
https://boris.unibe.ch/id/eprint/161344 |
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