Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span

Grunewald, M.; Kumar, S.; Sharife, H.; Volinsky, E.; Gileles-Hillel, A.; Licht, T.; Permyakova, A.; Hinden, L.; Azar, S.; Friedmann, Y.; Kupetz, P.; Tzuberi, R.; Anisimov, A.; Alitalo, K.; Horwitz, M.; Leebhoff, S.; Khoma, O. Z.; Hlushchuk, R.; Djonov, V.; Abramovitch, R.; ... (2021). Counteracting age-related VEGF signaling insufficiency promotes healthy aging and extends life span. Science, 373(6554) American Association for the Advancement of Science 10.1126/science.abc8479

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Aging is an established risk factor for vascular diseases, but vascular aging itself may contribute to the progressive deterioration of organ function. Here, we show in aged mice that vascular endothelial growth factor (VEGF) signaling insufficiency, which is caused by increased production of decoy receptors, may drive physiological aging across multiple organ systems. Increasing VEGF signaling prevented age-associated capillary loss, improved organ perfusion and function, and extended life span. Healthier aging was evidenced by favorable metabolism and body composition and amelioration of aging-associated pathologies including hepatic steatosis, sarcopenia, osteoporosis, "inflammaging" (age-related multiorgan chronic inflammation), and increased tumor burden. These results indicate that VEGF signaling insufficiency affects organ aging in mice and suggest that modulating this pathway may result in increased mammalian life span and improved overall health.

Item Type:

Journal Article (Original Article)

Division/Institute:

09 Interdisciplinary Units > Microscopy Imaging Center (MIC)
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Anatomy > Topographical and Clinical Anatomy

Graduate School:

Graduate School for Cellular and Biomedical Sciences (GCB)

UniBE Contributor:

Khoma, Oleksiy-Zakhar, Hlushchuk, Ruslan, Djonov, Valentin Georgiev

Subjects:

600 Technology > 610 Medicine & health

ISSN:

0036-8075

Publisher:

American Association for the Advancement of Science

Language:

English

Submitter:

Oleksiy-Zakhar Khoma

Date Deposited:

10 Jan 2022 12:15

Last Modified:

05 Dec 2022 15:56

Publisher DOI:

10.1126/science.abc8479

PubMed ID:

34326210

BORIS DOI:

10.48350/162238

URI:

https://boris.unibe.ch/id/eprint/162238

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