On Iron Metabolism and Its Regulation.

Vogt, Anne-Cathrine S.; Arsiwala, Tasneem; Mohsen, Mona; Vogel, Monique; Manolova, Vania; Bachmann, Martin F. (2021). On Iron Metabolism and Its Regulation. International journal of molecular sciences, 22(9) MDPI 10.3390/ijms22094591

Preview

Text ijms-22-04591.pdf - Published Version Available under License Creative Commons: Attribution (CC-BY). Download (10MB) | Preview

Iron is a critical metal for several vital biological processes. Most of the body's iron is bound to hemoglobin in erythrocytes. Iron from senescent red blood cells is recycled by macrophages in the spleen, liver and bone marrow. Dietary iron is taken up by the divalent metal transporter 1 (DMT1) in enterocytes and transported to portal blood via ferroportin (FPN), where it is bound to transferrin and taken up by hepatocytes, macrophages and bone marrow cells via transferrin receptor 1 (TfR1). While most of the physiologically active iron is bound hemoglobin, the major storage of most iron occurs in the liver in a ferritin-bound fashion. In response to an increased iron load, hepatocytes secrete the peptide hormone hepcidin, which binds to and induces internalization and degradation of the iron transporter FPN, thus controlling the amount of iron released from the cells into the blood. This review summarizes the key mechanisms and players involved in cellular and systemic iron regulation.

Interest & Impact

Downloads

226 since deposited on 19 Jan 2022
26 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item