Mitter, Vera Ruth; Fasel, Pascale; Berlin, Claudia; Amylidi-Mohr, Sofia; Mosimann, Beatrice; Zwahlen, Marcel; von Wolff, Michael; Kohl Schwartz, Alexandra Sabrina (2022). Perinatal outcomes in singletons after fresh IVF/ICSI: results of two cohorts and the birth registry. Reproductive biomedicine online, 44(4), pp. 689-698. Elsevier 10.1016/j.rbmo.2021.12.007
|
Text
Mitter_ReprodBiomedOnline_2022.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (1MB) | Preview |
RESEARCH QUESTION
How are perinatal outcomes of live-born singletons after stimulated and unstimulated IVF different from perinatal outcomes in (i) children born in a tertiary centre and (ii) all children born in Switzerland?
METHODS
This cohort study compared the perinatal outcomes of two birth cohorts and the national live birth registry. Relative risks were calculated using modified Poisson regression and clustering for siblings and adjustment for maternal age, parity and childs sex.
RESULTS
Of the 636,639 live births, 311 were in the Bern IVF Cohort (144 stimulated, 167 unstimulated), 2332 in the tertiary centre and 633,996 in the Swiss Live Birth Registry (SLBR). Perinatal outcomes following IVF did not differ compared with births in the SLBR (adjusted relative risk [aRR]; 95% confidence interval [CI]), with the exception of the increased risk of small for gestational age (1.31; 1.01 to 1.70, P = 0.04; aRR 1.12; 0.87 to 1.45, P = 0.39). Children born following stimulated IVF had a higher risk of low birthweight (2.17; 1.27 to 3.69, P < 0.01; aRR 1.72; 1.01 to 2.93, P = 0.05), and of being small for gestational age (1.50; 1.05 to 2.14, P = 0.03; aRR 1.31; 0.92 to 1.87; P = 0.13), whereas children born after unstimulated IVF had no increased risks compared with the SLBR. Higher Caesarean rate after IVF was mainly associated with higher maternal age.
CONCLUSION
Singletons in the Bern IVF Cohort do not show less favourable perinatal outcomes. Gonadotrophin stimulation seems to have an effect, because lower risks were associated with unstimulated IVF.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gynaecology, Paediatrics and Endocrinology (DFKE) > Clinic of Gynaecology 04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Mitter, Vera Ruth, Berlin, Claudia, Amylidi-Mohr, Sofia, Mosimann, Beatrice, von Wolff, Michael, Kohl Schwartz, Alexandra |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
1472-6483 |
Publisher: |
Elsevier |
Funders: |
[4] Swiss National Science Foundation |
Language: |
English |
Submitter: |
Andrea Flükiger-Flückiger |
Date Deposited: |
18 Feb 2022 11:25 |
Last Modified: |
02 Mar 2023 23:35 |
Publisher DOI: |
10.1016/j.rbmo.2021.12.007 |
PubMed ID: |
35151574 |
Uncontrolled Keywords: |
Assisted reproduction Epidemiology Gonadotrophins IVF/ICSI outcome Natural cycle |
BORIS DOI: |
10.48350/165655 |
URI: |
https://boris.unibe.ch/id/eprint/165655 |
Actions (login required)
 |
Edit item |