Du Puy, Robert S; Poortvliet, Rosalinde K E; Mooijaart, Simon P; Stott, David J; Quinn, Terry; Sattar, Naveed; Westendorp, Rudi G J; Kearney, Patricia M; McCarthy, Vera J C; Byrne, Stephen; Rodondi, Nicolas; Baretella, Oliver; Collet, Tinh-Hai; van Heemst, Diana; Dekkers, Olaf M; Jukema, J Wouter; Smit, Johannes W A; Gussekloo, Jacobijn; den Elzen, Wendy P J (2022). No effect of levothyroxine on hemoglobin in older adults with subclinical hypothyroidism: pooled results from two RCTs. Journal of clinical endocrinology and metabolism, 107(6), e2339-e2347. Endocrine Society 10.1210/clinem/dgac106
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CONTEXT
Subclinical thyroid dysfunction and anemia are common disorders, and both have increasing prevalence numbers with advancing age.
OBJECTIVE
The aim of this study was to assess whether levothyroxine treatment leads to a rise in hemoglobin levels in older persons with subclinical hypothyroidism.
DESIGN
A pre-planned combined analysis of two randomized controlled trials.
PARTICIPANTS
Community-dwelling persons aged 65 years and older with subclinical hypothyroidism.
INTERVENTION
Participants were randomly assigned to levothyroxine or placebo treatment. The dose of levothyroxine was periodically titrated aiming at thyroid stimulating hormone (TSH) level within the reference range and mock titrations in the placebo group.
MAIN OUTCOME MEASURE
The main outcome measure was the change in hemoglobin level after 12 months.
RESULTS
Analyses included 669 participants (placebo n=337, levothyroxine n=332) with a median age of 75 years (range 65 to 97) and mean baseline hemoglobin of 13.8±1.3 g/dL. Although levothyroxine treatment resulted in a reduction in TSH from baseline after 12 months of follow-up compared to placebo, the change in hemoglobin level was not different between the levothyroxine and the placebo groups (-0.03 g/dL [95%CI -0.16 to 0.11]). Similar results were found in stratified analyses including sex, age or TSH levels. No difference in change of hemoglobin levels after 12 months was identified in 69 participants with anemia at baseline (-0.33 g/dL [95% CI -0.87 to 0.21]).
CONCLUSIONS
In persons aged 65 years and older with subclinical hypothyroidism, treatment with levothyroxine does not lead to a rise in hemoglobin levels, regardless of the presence of anemia.
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