Kling, Kerstin; Domingo, Cristina; Bogdan, Christian; Duffy, Steven; Harder, Thomas; Howick, Jeremy; Kleijnen, Jos; McDermott, Kevin; Wichmann, Ole; Wilder-Smith, Annelies; Wolff, Robert (2022). Duration of protection after vaccination against yellow fever - systematic review and meta-analysis. Clinical infectious diseases, 75(12), pp. 2266-2274. Oxford University Press 10.1093/cid/ciac580
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The duration of protection after a single dose of yellow fever vaccine is a matter of debate. To summarize the current knowledge, we performed a systematic literature review and meta-analysis. Studies on the duration of protection after 1 and ≥2 vaccine doses were reviewed. Data were stratified by time since vaccination. In our meta-analysis, we used random-effects models. We identified 36 studies from 20 countries, comprising over 17,000 participants aged 6 months to 85 years. Among healthy adults and children, pooled seroprotection rates after single vaccination dose were close to 100% by 3 months and remained high in adults for 5 to 10 years. In children vaccinated before age 2, the seroprotection rate was 52% within 5 years after primary vaccination. For immunodeficient persons, data indicate relevant waning. The extent of waning of seroprotection after yellow fever vaccination depends on age at vaccination and immune status.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Wilder-Smith, Annelies |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
1537-6591 |
Publisher: |
Oxford University Press |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
25 Jul 2022 12:43 |
Last Modified: |
21 Jul 2023 00:25 |
Publisher DOI: |
10.1093/cid/ciac580 |
PubMed ID: |
35856638 |
Uncontrolled Keywords: |
duration of protection immunodeficiency risk group systematic review yellow fever vaccine |
BORIS DOI: |
10.48350/171487 |
URI: |
https://boris.unibe.ch/id/eprint/171487 |
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