Cole, Connor; Vinay, Keshavamurthy; Borradori, Luca; Amber, Kyle T (2022). Insights Into the Pathogenesis of Bullous Pemphigoid: The Role of Complement-Independent Mechanisms. Frontiers in immunology, 13, p. 912876. Frontiers Research Foundation 10.3389/fimmu.2022.912876
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Bullous pemphigoid is an autoimmune blistering disease caused by autoantibodies targeting BP180 and BP230. While deposits of IgG and/or complement along the epidermal basement membrane are typically seen suggesting complement -mediated pathogenesis, several recent lines of evidence point towards complement-independent pathways contributing to tissue damage and subepidermal blister formation. Notable pathways include macropinocytosis of IgG-BP180 complexes resulting in depletion of cellular BP180, direct induction of pro-inflammatory cytokines from keratinocytes, as well as IgE autoantibody- and eosinophil-mediated effects. We review these mechanisms which open new perspectives on novel targeted treatment modalities.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Dermatology |
UniBE Contributor: |
Borradori, Luca |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1664-3224 |
Publisher: |
Frontiers Research Foundation |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
26 Jul 2022 13:05 |
Last Modified: |
05 Dec 2022 16:22 |
Publisher DOI: |
10.3389/fimmu.2022.912876 |
PubMed ID: |
35874745 |
Uncontrolled Keywords: |
BP180 BP230 autoimmune blistering diseases bullous pemphigoid complement - immunological terms eosinophils – immunology igE (Immunoglobulin E) |
BORIS DOI: |
10.48350/171535 |
URI: |
https://boris.unibe.ch/id/eprint/171535 |
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