Hapfelmeier, Siegfried; Macpherson, Andrew J. (2010). In remembrance of commensal intestinal microbes. Communicative & integrative biology, 3(6), pp. 569-571. Austin, Tex.: Landes Bioscience 10.4161/cib.3.6.13011
Full text not available from this repository.Mammals contain an enormous load of commensal microbes in the lower intestine, which induce adaptive responses in the host immune system that ensure mutual coexistence of the host and its microbial passengers. The main way of studying how the host responds to commensal colonization has been to compare animals kept in entirely germ-free conditions and their colonized counterparts. We present an overview of our development of a reversible colonization system, whereby germ free animals can be treated with live commensal bacteria that do not persist in the host, so it becomes germ free again. We describe how this system has been used to demonstrate that there is little or no immune memory for specific IgA induction in the intestinal mucosal immune system by commensal intestinal bacteria.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Service Sector > Institute for Infectious Diseases > Research 04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Gastroenterology |
UniBE Contributor: |
Hapfelmeier, Siegfried Hektor, Macpherson, Andrew |
ISSN: |
1942-0889 |
Publisher: |
Landes Bioscience |
Language: |
English |
Submitter: |
Siegfried Hektor Hapfelmeier-Balmer |
Date Deposited: |
04 Oct 2013 14:11 |
Last Modified: |
05 Dec 2022 14:01 |
Publisher DOI: |
10.4161/cib.3.6.13011 |
PubMed ID: |
21331242 |
URI: |
https://boris.unibe.ch/id/eprint/1721 (FactScience: 203657) |
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