Coluccia, Daniel; Fandino, Javier; Marbacher, Serge; Erhardt, Salome; Kienzler, Jenny; Martin, Ernst; Werner, Beat (2014). A microsurgical bifurcation rabbit model to investigate the effect of high-intensity focused ultrasound on aneurysms: a technical note. Journal of therapeutic ultrasound, 2, p. 21. Biomed Central 10.1186/2050-5736-2-21
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BACKGROUND
Recent clinical studies confirmed the high potential of MR-guided focused ultrasound (MRgFUS) in the field of functional neurosurgery. While its ability for precise thermo-ablation within soft tissue is widely recognized, the impact of high-intensity focused ultrasound (HIFU) on larger vessels is less explored. We used a bifurcation aneurysm model in rabbits to investigate the possible effects on the walls of vascular aneurysms and to assess the risk and prospect of this procedure for managing neurovascular disorders.
METHODS
Experimental bifurcation aneurysms were microsurgically created in New Zealand white rabbits and sonicated using MRgFUS.
RESULTS
A temperature of max. 54°C could be achieved close to the aneurysm, and the shape and size of the aneurysm were noticeably changed, as shown by MR angiography.
CONCLUSIONS
The presented rabbit model proved suitable and capable of being extended to acquire data on the effect of HIFU on aneurysms and larger vessels. The fact that HIFU led to an alteration of the aneurysm without inducing rupture encourages further investigations.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Intensive Care, Emergency Medicine and Anaesthesiology (DINA) > Clinic of Intensive Care 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Pavillon 52 > Forschungsgruppe Intensivmedizin 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Neurochirurgie |
UniBE Contributor: |
Coluccia, Daniel, Erhardt, Salome Aglaia |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2050-5736 |
Publisher: |
Biomed Central |
Language: |
English |
Submitter: |
Marceline Brodmann |
Date Deposited: |
21 Sep 2022 10:10 |
Last Modified: |
05 Dec 2022 16:25 |
Publisher DOI: |
10.1186/2050-5736-2-21 |
PubMed ID: |
25512871 |
Uncontrolled Keywords: |
Aneurysm Focused ultrasound Rabbit model Sonication |
BORIS DOI: |
10.48350/173108 |
URI: |
https://boris.unibe.ch/id/eprint/173108 |
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