Leeb, Tosso; Bannasch, Danika; Schoenebeck, Jeffrey J (2023). Identification of Genetic Risk Factors for Monogenic and Complex Canine Diseases. Annual Review of Animal Biosciences, 11, pp. 183-205. Annual Reviews 10.1146/annurev-animal-050622-055534
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Advances in DNA sequencing and other technologies have greatly facilitated the identification of genetic risk factors for inherited diseases in dogs. We review recent technological developments based on selected examples from canine disease genetics. The identification of disease-causing variants in dogs with monogenic diseases may become a widely employed diagnostic approach in clinical veterinary medicine in the not-too-distant future. Diseases with complex modes of inheritance continue to pose challenges to researchers but have also become much more tangible than in the past. In addition to strategies for identifying genetic risk factors, we provide some thoughts on the interpretation of sequence variants that are largely inspired by developments in human clinical genetics. Expected final online publication date for the Annual Review of Animal Biosciences, Volume 11 is February 2023. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
Item Type: |
Journal Article (Review Article) |
|---|---|
Division/Institute: |
05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) > Institute of Genetics 05 Veterinary Medicine > Department of Clinical Research and Veterinary Public Health (DCR-VPH) |
UniBE Contributor: |
Leeb, Tosso |
Subjects: |
500 Science > 570 Life sciences; biology 500 Science > 590 Animals (Zoology) 600 Technology > 610 Medicine & health |
ISSN: |
2165-8110 |
Publisher: |
Annual Reviews |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
03 Nov 2022 10:38 |
Last Modified: |
20 Feb 2023 13:55 |
Publisher DOI: |
10.1146/annurev-animal-050622-055534 |
PubMed ID: |
36322969 |
BORIS DOI: |
10.48350/174444 |
URI: |
https://boris.unibe.ch/id/eprint/174444 |
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