Kaur, Savneet; Kidambi, Sri; Ortega-Ribera, Martí; Thanh Thuy, Le Thi; Nieto, Natalia; Cogger, Victoria C; Xie, Wei-Fen; Tacke, Frank; Gracia-Sancho, Jordi (2023). In vitro models for the study of liver biology and diseases - advances and limitations. Cellular and molecular gastroenterology and hepatology, 15(3), pp. 559-571. Elsevier 10.1016/j.jcmgh.2022.11.008
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In vitro models of liver (patho)physiology, new technologies and experimental approaches are progressing rapidly. Based on cell lines, induced pluripotent stem cells (iPSCs) or primary cells derived from mouse or human liver as well as whole tissue (slices), such in vitro single- and multi-cellular models, including complex microfluidic organ-on-a-chip systems, provide tools to functionally understand mechanisms of liver health and disease. The International Society of Hepatic Sinusoidal Research (ISHSR) commissioned this working group to review the currently available in vitro liver models and describe the advantages and disadvantages of each in the context of evaluating their use for the study of liver functionality, disease modelling, therapeutic discovery and clinical applicability.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology |
UniBE Contributor: |
Jordi, Gracia |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
2352-345X |
Publisher: |
Elsevier |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
29 Nov 2022 14:56 |
Last Modified: |
23 May 2023 18:48 |
Publisher DOI: |
10.1016/j.jcmgh.2022.11.008 |
PubMed ID: |
36442812 |
Uncontrolled Keywords: |
Hepatic sinusoid NAFLD NASH bioengineering cirrhosis mechanobiology omics |
BORIS DOI: |
10.48350/175273 |
URI: |
https://boris.unibe.ch/id/eprint/175273 |
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