Gyimesi, Gergely; Hediger, Matthias A (2023). Transporter-Mediated Drug Delivery. Molecules, 28(3) MDPI 10.3390/molecules28031151
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Transmembrane transport of small organic and inorganic molecules is one of the cornerstones of cellular metabolism. Among transmembrane transporters, solute carrier (SLC) proteins form the largest, albeit very diverse, superfamily with over 400 members. It was recognized early on that xenobiotics can directly interact with SLCs and that this interaction can fundamentally determine their efficacy, including bioavailability and intertissue distribution. Apart from the well-established prodrug strategy, the chemical ligation of transporter substrates to nanoparticles of various chemical compositions has recently been used as a means to enhance their targeting and absorption. In this review, we summarize efforts in drug design exploiting interactions with specific SLC transporters to optimize their therapeutic effects. Furthermore, we describe current and future challenges as well as new directions for the advanced development of therapeutics that target SLC transporters.
Item Type: |
Journal Article (Review Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Unit Childrens Hospital > Forschungsgruppe Nephrologie / Hypertonie 04 Faculty of Medicine > Department of Dermatology, Urology, Rheumatology, Nephrology, Osteoporosis (DURN) > Clinic of Nephrology and Hypertension |
UniBE Contributor: |
Gyimesi, Gergely (A), Hediger, Matthias |
Subjects: |
600 Technology > 610 Medicine & health |
ISSN: |
1420-3049 |
Publisher: |
MDPI |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
13 Feb 2023 12:30 |
Last Modified: |
07 Aug 2024 15:45 |
Publisher DOI: |
10.3390/molecules28031151 |
PubMed ID: |
36770817 |
Uncontrolled Keywords: |
SLC bile acids drug design membrane transporter nanoparticle pharmacokinetics prodrug solute carrier |
BORIS DOI: |
10.48350/178681 |
URI: |
https://boris.unibe.ch/id/eprint/178681 |
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