Shared and separate patterns in brain morphometry across transdiagnostic dimensions.

McCutcheon, Robert A.; Pillinger, Toby; Guo, Xin; Rogdaki, Maria; Welby, George; Vano, Luke; Cummings, Connor; Ann-Heron, Toni; Brugger, Stefan; Davies, David; Ghanem, Mawada; Efthimiou, Orestis; Cipriani, Andrea; Howes, Oliver D. (2023). Shared and separate patterns in brain morphometry across transdiagnostic dimensions. Nature Mental Health, 1(1), pp. 55-65. Springer Nature 10.1038/s44220-022-00010-y

Preview	Text McCutcheon_NatureMentalHealth_2022_AAM.pdf - Accepted Version Available under License Publisher holds Copyright. Download (1MB) | Preview
	Text McCutcheon_NatureMentalHealth_2023.pdf - Published Version Restricted to registered users only Available under License Publisher holds Copyright. Download (1MB) | Request a copy

Determining similarities and differences in brain structure across psychiatric disorders is important to determine if psychiatric taxonomy is reflected in distinct brain structural changes. As previous neuroimaging meta-analyses have typically focused on a single disorder, precluding transdiagnostic comparisons, we aimed to quantify patterns of similarity and differences between psychiatric disorders in terms of regional brain volumes. Here we show, in network and pairwise meta-analyses of 498 studies (51,227 individuals, 17 psychiatric disorders and 17 brain regions), that psychiatric disorders show both distinct and overlapping patterns of brain volume gain and loss. A principal components analysis demonstrated that the first principal component could account for 48% of variance and corresponded to a pattern of increased basal ganglia and decreased hippocampal and amygdala volumes. This component loaded most strongly for disorders on the psychosis spectrum, and most weakly for affective disorders. Our findings illustrated that, while similar volumetric alterations are frequently shared between disorders, neuroanatomical patterns also appear related to clinically meaningful categories. (PROSPERO Registration: CRD42020221143.)

Interest & Impact

Downloads

2 since deposited on 16 Mar 2023
2 in the past 12 months

Citations

5 Citations in Web of Science ®
6 Citations in Scopus

Search

in Google Scholar™

Services

Actions (login required)

Edit item

Actions (login required)

Edit item