Barth, Florian; Gerber, Peter J; Reichen, Jürg; Dufour, Jean-François; Nicod, Laurent P (2006). Efficiency and safety of bosentan in child C cirrhosis with portopulmonary hypertension and renal insufficiency. European journal of gastroenterology & hepatology, 18(10), pp. 1117-9. Hagerstown, Md.: Lippincott Williams & Wilkins 10.1097/01.meg.0000231749.60889.f7
Full text not available from this repository.Bosentan has lately been described as a successful therapeutic agent for portopulmonary hypertension consecutive to child A cirrhosis. This is the first report of the effect of this substance with advanced liver cirrhosis (child C) and renal insufficiency. Low doses of bosentan (initially twice 31.25 mg/day and then 62.5 mg/day) increased cardiac output and allowed correction of renal insufficiency; it allowed one to stop the requirement of oxygen and not only improved the 6-min walking test by more than 400 m, but also decreased the severity of the liver cirrhosis to child B stadium. This suggests that patients, who would be excluded from a liver transplantation program because of their portopulmonary hypertension, could profit from a careful therapy with bosentan.
Item Type: |
Journal Article (Original Article) |
|---|---|
Division/Institute: |
04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Pneumology 04 Faculty of Medicine > Service Sector > Institute of Clinical Pharmacology and Visceral Research [discontinued] 04 Faculty of Medicine > Department of Gastro-intestinal, Liver and Lung Disorders (DMLL) > Clinic of Visceral Surgery and Medicine > Hepatology |
UniBE Contributor: |
Gerber, Peter, Reichen, Jürg, Dufour, Jean-François, Nicod, Laurent |
ISSN: |
0954-691X |
ISBN: |
16957519 |
Publisher: |
Lippincott Williams & Wilkins |
Language: |
English |
Submitter: |
Factscience Import |
Date Deposited: |
04 Oct 2013 14:45 |
Last Modified: |
05 Dec 2022 14:14 |
Publisher DOI: |
10.1097/01.meg.0000231749.60889.f7 |
PubMed ID: |
16957519 |
Web of Science ID: |
000243646000013 |
URI: |
https://boris.unibe.ch/id/eprint/18542 (FactScience: 734) |
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