Arfman, Tom; Zollet, Valentina; van Es, Nick; Bosch, Floris T M; Nicolaes, Gerry A F; Sorvillo, Nicoletta; Voorberg, Jan (2024). Elevated levels of citrullinated fibrinogen in patients with cancer. eJHaem, 5(1), pp. 136-140. Wiley 10.1002/jha2.825
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eJHaem_-_2024_-_Arfman_-_Elevated_levels_of_citrullinated_fibrinogen_in_patients_with_cancer.pdf - Published Version Available under License Creative Commons: Attribution-Noncommercial-No Derivative Works (CC-BY-NC-ND). Download (690kB) | Preview |
Neutrophil released peptidyl arginine deiminase 4 (PAD4) converts arginine residues on plasma proteins into citrulline. Here, we developed an assay to quantify citrullinated fibrinogen. We employed a biotin-conjugated phenylglyoxal (biotin-phenylglyoxal (PG)) compound that selectively labels citrulline. Patient samples were derived from a multicenter prospective cohort study that aimed to identify cancer patients at high risk for venous thromboembolism (VTE). Our data show that cancer patients have higher (median 2-fold increased) citrullinated fibrinogen levels when compared to normal human plasma and a cohort of healthy donors. Our results show that citrullination of fibrinogen is a common posttranslational modification in patients with cancer.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 > Forschungsgruppe Herz und Gefässe 04 Faculty of Medicine > Pre-clinic Human Medicine > BioMedical Research (DBMR) > Forschungsbereich Mu50 |
Graduate School: |
Graduate School for Cellular and Biomedical Sciences (GCB) |
UniBE Contributor: |
Zollet, Valentina, Sorvillo, Nicoletta |
Subjects: |
500 Science > 570 Life sciences; biology 600 Technology > 610 Medicine & health |
ISSN: |
2688-6146 |
Publisher: |
Wiley |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
26 Feb 2024 16:21 |
Last Modified: |
26 Feb 2024 16:29 |
Publisher DOI: |
10.1002/jha2.825 |
PubMed ID: |
38406510 |
Uncontrolled Keywords: |
cancer citrullination coagulation fibrinogen thrombosis |
BORIS DOI: |
10.48350/193270 |
URI: |
https://boris.unibe.ch/id/eprint/193270 |
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