The prognostic value of tumor budding in a thoroughly characterized stage II colon cancer population in the context of a national screening program.

Pihlmann Kristensen, Maria; Korsgaard, Ulrik; Timm, Signe; Hansen, Torben Frøstrup; Zlobec, Inti; Hager, Henrik; Kjær-Frifeldt, Sanne (2024). The prognostic value of tumor budding in a thoroughly characterized stage II colon cancer population in the context of a national screening program. Human pathology, 146, pp. 15-22. Elsevier 10.1016/j.humpath.2024.02.010

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Tumor budding as a prognostic marker in colorectal cancer has not previously been investigated in a cohort of screened stage II colon cancer patients. We assess the prognostic significance of tumor budding in a thoroughly characterized stage II colon cancer population comprising surgically resected patients in the Region of Southern Denmark from 2014 to 2016. Tumors were re-staged according to the 8th edition of UICC TNM Classification, undergoing detailed histopathological evaluation and tumor budding assessment following guidelines from the International Tumor Budding Consensus Conference. Prognostic evaluation utilized Kaplan-Meier curves, log-rank tests, and Cox proportional hazard models for time to recurrence (TTR), recurrence-free survival (RFS), and overall survival (OS). Out of 497 patients, 20% were diagnosed through the national colorectal cancer screening program. High-grade tumor budding (Bd3) was found in 19%, and tumor budding was associated with glandular subtype, perineural invasion, mismatch repair proficient tumors, and tumor recurrence (p < 0.001, p < 0.001, p = 0.045 and p = 0.007 respectively). In multivariable Cox regression, high-grade tumor budding (Bd3) was a significant prognostic factor for TTR compared to low-grade (Bd3 HR 2.617; p = 0.007). An association between tumor budding groups and RFS was observed, and the difference was significant in univariable analysis for high-grade compared to low-grade tumor budding (Bd3 HR 1.461; p = 0.041). No significant differences were observed between tumor budding groups and OS. High-grade tumor budding is a predictor of recurrence in a screened population of patients with stage II colon cancer and should be considered a high-risk factor in a shared decision-making process when stratifying patients to adjuvant chemotherapy.

Item Type:

Journal Article (Original Article)

Division/Institute:

04 Faculty of Medicine > Service Sector > Institute of Pathology

UniBE Contributor:

Zlobec, Inti

Subjects:

500 Science > 570 Life sciences; biology
600 Technology > 610 Medicine & health

ISSN:

0046-8177

Publisher:

Elsevier

Language:

English

Submitter:

Pubmed Import

Date Deposited:

04 Mar 2024 14:17

Last Modified:

06 May 2024 00:14

Publisher DOI:

10.1016/j.humpath.2024.02.010

PubMed ID:

38428823

Uncontrolled Keywords:

Directed acyclic graph Screening Survival Tumor budding UICC stage II colon cancer

BORIS DOI:

10.48350/193725

URI:

https://boris.unibe.ch/id/eprint/193725

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