Simoes, Margarida Pires; Hodcroft, Emma B; Simmonds, Peter; Albert, Jan; Alidjinou, Enagon K; Ambert-Balay, Katia; Andrés, Cristina; Antón, Andrés; Auvray, Christelle; Bailly, Jean-Luc; Baldanti, Fausto; Bastings, Capser; Beard, Stuart; Pereira, Carla Berengua; Berginc, Natasa; Bloemen, Mandy; Blomqvist, Soile; Bosma, Froukje; Böttcher, Sindy; Bubba, Laura; ... (2024). Epidemiological and clinical insights into the enterovirus D68 upsurge in Europe 2021/22 and the emergence of novel B3-derived lineages, ENPEN multicentre study. (In Press). Journal of infectious diseases Oxford University Press 10.1093/infdis/jiae154
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Enterovirus D68 (EV-D68) infections are associated with severe respiratory disease and acute flaccid myelitis (AFM). The European Non-Polio Enterovirus Network (ENPEN) aimed to investigate the epidemiological and genetic characteristics of EV-D68 and its clinical impact during the fall-winter season of 2021/22. From 19 European countries, 58 institutes reported 10,481 (6.8%) EV-positive samples of which 1,004 (9.6%) were identified as EV-D68 (852 respiratory samples). Clinical data was reported for 969 cases. 78.9% of infections were reported in children (0-5 years); 37.9% of cases were hospitalised. Acute respiratory distress was commonly noted (93.1%) followed by fever (49.4%). Neurological problems were observed in 6.4% of cases with six reported with AFM. Phylodynamic/Nextstrain and phylogenetic analyses based on 694 sequences showed the emergence of two novel B3-derived lineages, with no regional clustering. In conclusion, we describe a large-scale EV-D68 European upsurge with severe clinical impact and the emergence of B3-derived lineages.
Item Type: |
Journal Article (Original Article) |
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Division/Institute: |
04 Faculty of Medicine > Pre-clinic Human Medicine > Institute of Social and Preventive Medicine (ISPM) |
UniBE Contributor: |
Hodcroft, Emma Britt |
Subjects: |
600 Technology > 610 Medicine & health 300 Social sciences, sociology & anthropology > 360 Social problems & social services |
ISSN: |
0022-1899 |
Publisher: |
Oxford University Press |
Funders: |
[4] Swiss National Science Foundation |
Language: |
English |
Submitter: |
Pubmed Import |
Date Deposited: |
03 Apr 2024 14:25 |
Last Modified: |
04 Apr 2024 14:06 |
Publisher DOI: |
10.1093/infdis/jiae154 |
PubMed ID: |
38547499 |
Uncontrolled Keywords: |
B3-derived lineages European Non-Polio Enterovirus Network (ENPEN) acute flaccid myelitis (AFM) acute flaccid paralysis (AFP) coronavirus disease caused by SARS-CoV-2 (COVID-19) enterovirus D68 (EV-D68) non-polio enterovirus (NPEV) respiratory infection surveillance |
BORIS DOI: |
10.48350/195296 |
URI: |
https://boris.unibe.ch/id/eprint/195296 |
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